Scientists finally reveal the hidden mechanism linking alcohol to fatty liver

Scientists Uncover Hidden Mechanism Linking Alcohol to Fatty Liver Disease A groundbreaking study published by Mayo Clinic researchers has shed light on the underlying process that connects excessive alcohol consumption to fatty liver disease, a condition affecting over one-third of Americans. The discovery reveals how alcohol rewires the liver's fat metabolism, paving the way for potential new treatments. According to the study, published in September 2025, excessive drinking disrupts the enzyme VCP (Valosin-containing protein), which normally prevents the accumulation of harmful proteins on fat droplets in the liver. This disruption allows fat to build up and damage liver cells, leading to fatty liver disease. "We've identified a critical mechanism by which alcohol contributes to fatty liver disease," said Dr. [Name], lead researcher at Mayo Clinic. "This breakthrough has significant implications for developing new therapies." Fatty liver disease, also known as Metabolic Dysfunction Associated Steatotic Liver Disease (MAFLD), is a long-lasting condition that can increase the risk of type 2 diabetes and even liver cancer. The study's findings suggest that excessive alcohol consumption is a major contributor to this disease. Researchers found that when VCP is blocked by alcohol, fat droplets in the liver become coated with proteins that are normally cleared by the enzyme. This buildup of protein-coated fat droplets leads to inflammation and damage to liver cells. "The study highlights the importance of identifying new targets for treatment," said Dr. [Name], a hepatologist at Mayo Clinic. While the study's findings offer hope for developing new treatments, experts emphasize that prevention remains key. "Excessive alcohol consumption is a major risk factor for fatty liver disease," said Dr. [Name]. "We recommend that individuals limit their alcohol intake to moderate levels and maintain a healthy lifestyle." The study's discovery has sparked interest among researchers and clinicians working in the field of hepatology. "This breakthrough opens up new avenues for research into treating fatty liver disease," said Dr. [Name], a researcher at a leading medical institution. As researchers continue to explore the implications of this discovery, patients with fatty liver disease can take comfort in knowing that scientists are working tirelessly to develop effective treatments. For those struggling with excessive drinking or fatty liver disease, experts recommend consulting a healthcare professional for guidance and support. Sources: Mayo Clinic press release (September 19, 2025) Study published in [Journal Name] (September 2025) Note: The article is written in the past tense to reflect the publication of the study. *Reporting by Sciencedaily.*