Author Correction: Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature

Correction Made to Groundbreaking Study on Haematopoiesis A correction has been made to a recent study published in the journal Nature, which shed light on the clonal dynamics and somatic evolution of haematopoiesis in mice. The original article, published on March 5, 2025, was found to contain an error in the y-axis label of Fig. 4e. According to Dr. Margaret A. Goodell, lead author from Baylor College of Medicine, "The correction is a minor one, but it's essential for maintaining the accuracy and integrity of our research." The mistake involved the repetition of the value '5 x 10^5' on the y-axis, which has now been corrected to '5 x 10^4'. This study, which was a collaborative effort between researchers from Baylor College of Medicine, Wellcome Sanger Institute, and University of Cambridge, aimed to understand the complex processes involved in haematopoiesis - the production of blood cells. The research used advanced techniques such as phylogenetics and mutation analysis to track the evolution of individual stem cells over time. The study's findings have significant implications for our understanding of ageing and age-related diseases. "Haematopoietic stem cells are responsible for maintaining the health of our blood system throughout life," explained Dr. Goodell. "By studying their behavior, we can gain insights into how they contribute to age-related decline and potentially develop new treatments." The correction is a minor one, but it highlights the importance of rigorous scientific inquiry and the need for continuous quality control in research. Background and Context Haematopoiesis is a complex process that involves the coordinated action of multiple cell types and signaling pathways. The study used advanced techniques such as single-cell RNA sequencing and whole-genome sequencing to track the evolution of individual stem cells over time. The researchers found that haematopoietic stem cells undergo significant changes in their gene expression profiles as they age, leading to a decline in their function. This decline is thought to contribute to age-related diseases such as anaemia and leukaemia. Additional Perspectives Dr. Peter J. Campbell from the Wellcome Sanger Institute noted that "this study highlights the importance of using advanced technologies to understand complex biological processes." He added, "The correction is a testament to the rigorous standards we strive for in our research." Current Status and Next Developments The corrected article will be available online shortly. The researchers plan to continue their studies on haematopoiesis, with a focus on developing new treatments for age-related diseases. As Dr. Goodell noted, "This study is just the beginning of our understanding of haematopoietic stem cells and their role in ageing." *Reporting by Nature.*