Psilocybin's Lasting Effects Hinge on Specific Brain Cells and Receptors

CORRECTION NOTICE: Psilocybin's Lasting Action Requires Specific Cell Types and Receptors A recent study published in the journal Nature has been corrected to reflect errors in figure labels. The correction highlights the importance of pyramidal cell types and 5-HT2A receptors in psilocybin's lasting action. According to the original article, researchers from Cornell University and Yale University School of Medicine found that psilocybin, a psychedelic compound found in certain mushrooms, has a lasting impact on neural circuits. The study, published on April 2, 2025, suggested that this effect is mediated by pyramidal cell types and 5-HT2A receptors. However, upon further review, the authors discovered errors in figure labels, specifically in Fig. 3e, h, k, n and Extended Data Fig. 7b-e x-axis labels. The corrected figures have been updated in both the HTML and PDF versions of the article. "We are grateful for the opportunity to correct these errors," said Dr. Ling-Xiao Shao, co-author of the study. "Our research aims to understand the neural mechanisms underlying psilocybin's effects, and we believe that this correction will help to further clarify our findings." The original study built on previous research into the effects of psychedelics on the brain. Psilocybin has been shown to have therapeutic potential in treating mental health disorders such as depression and anxiety. "This correction is an important step forward in our understanding of psilocybin's mechanisms," said Dr. Alex C. Kwan, co-author of the study. "We hope that this research will contribute to the development of new treatments for mental health conditions." The corrected article has been updated online, and researchers are continuing to explore the implications of their findings. Background: Psilocybin is a psychedelic compound found in certain mushrooms. It has been studied extensively for its potential therapeutic benefits, including treating depression and anxiety. The study's authors used advanced imaging techniques to investigate the neural mechanisms underlying psilocybin's effects. Implications: The correction highlights the importance of accurate labeling in scientific research. It also underscores the significance of pyramidal cell types and 5-HT2A receptors in mediating psilocybin's lasting action. "This correction demonstrates the value of rigorous scientific inquiry," said Dr. Neil K. Savalia, co-author of the study. "We hope that our research will contribute to a better understanding of the neural mechanisms underlying psychedelic effects." Next Developments: Researchers are continuing to explore the therapeutic potential of psilocybin and other psychedelics. The corrected article is an important step forward in this research. "We believe that our findings have significant implications for the development of new treatments for mental health conditions," said Dr. Clara Liao, co-author of the study. "We look forward to continuing our research in this area." *Reporting by Nature.*