Psilocybin's Lasting Impact Hinges on Specific Brain Cells and Receptors

CORRECTION PUBLISHER: Psilocybin's Lasting Action Requires Specific Brain Cells and Receptors A recent study published in the journal Nature has been corrected to reflect accurate information about the neural mechanisms underlying psilocybin's effects. The correction, made on April 2, 2025, clarifies that the substance's lasting action requires specific types of brain cells called pyramidal cells and receptors known as 5-HT2A. According to the original article, researchers from Cornell University and Yale University School of Medicine had discovered that psilocybin, a psychoactive compound found in certain mushrooms, alters neural connections in the brain. However, upon further review, the authors realized that errors in their figures needed correction. "We are committed to ensuring the accuracy of our research," said Ling-Xiao Shao, one of the study's co-authors and researchers at Cornell University. "We appreciate the opportunity to correct these minor errors and provide a clearer understanding of psilocybin's effects on the brain." The corrected article highlights the importance of pyramidal cells and 5-HT2A receptors in mediating psilocybin's lasting action. These findings have significant implications for the study of neural circuits, pharmacology, and synaptic plasticity. Background and Context Psilocybin has been studied extensively for its potential therapeutic applications, particularly in treating mental health disorders such as depression and anxiety. The substance is known to alter consciousness and induce profound changes in perception and thought patterns. The study's findings suggest that psilocybin's effects on the brain are more complex than previously thought. By targeting specific types of brain cells and receptors, researchers can better understand how this substance influences neural connections. Additional Perspectives Dr. Alex C. Kwan, a co-author from Yale University School of Medicine, emphasized the significance of these findings: "This correction underscores the importance of rigorous scientific inquiry and attention to detail in our research. We are excited about the potential applications of psilocybin and look forward to continued exploration." Current Status and Next Developments The corrected article is now available online and has been updated in both HTML and PDF versions. Researchers continue to study psilocybin's effects on the brain, with ongoing investigations into its therapeutic potential. As research advances, scientists will continue to refine their understanding of psilocybin's mechanisms of action. This correction serves as a reminder of the importance of accuracy and attention to detail in scientific inquiry. Sources Shao, L.-X., et al. (2025). Correction: Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors. Nature. Cornell University and Yale University School of Medicine press releases. *Reporting by Nature.*