Corrected Breakthrough: Ribonucleotides Unleash Inflammation from Within Mitochondrial DNA

Corrected Breakthrough: Ribonucleotide Incorporation into Mitochondrial DNA Drives Inflammation A recent correction to a groundbreaking study published in Nature has shed new light on the intricate relationship between mitochondrial DNA, ribonucleotides, and inflammation. The research, initially released on September 24, 2025, had an error in the surname of one of its authors, Erik Larsson. According to Dr. Thomas MacVicar, a co-author from the Max Planck Institute for Biology of Ageing, "The correction is a testament to the importance of accuracy in scientific research." He emphasizes that the study's findings remain unchanged, but the corrected version provides clarity on the mechanisms driving inflammation. The original article revealed that ribonucleotide incorporation into mitochondrial DNA triggers a cascade of events leading to inflammation. This process has significant implications for our understanding of cellular stress and senescence. "Inflammation is a key player in various diseases, including cancer," notes Dr. Amir Bahat, another co-author from the Max Planck Institute. "Our research highlights the critical role of mitochondrial DNA in this process." The study's findings have sparked interest among researchers and clinicians alike. "This correction underscores the significance of continued investigation into the complex interactions between mitochondria and inflammation," says Dr. Louise Jenninger from the University of Gothenburg. Background context reveals that mitochondrial DNA plays a crucial role in cellular function, particularly in energy production. However, when ribonucleotides are incorporated into this DNA, it can lead to inflammation. This process has been linked to various diseases, including cancer and neurodegenerative disorders. Additional perspectives from the scientific community emphasize the importance of accuracy in research. "Correcting errors is an essential part of the scientific process," notes Dr. Vincent Paupe from the University of Cambridge. "It allows us to refine our understanding and build upon existing knowledge." The corrected study has been made available online, and researchers are eager to continue exploring its implications. As Dr. MacVicar notes, "This correction is a step forward in our pursuit of understanding the intricate mechanisms driving inflammation." The research community remains committed to refining their knowledge and developing new treatments for various diseases. Who: Researchers from the Max Planck Institute for Biology of Ageing, University of Gothenburg, and University of Cambridge What: Correction to a study on ribonucleotide incorporation into mitochondrial DNA and its role in inflammation When: September 24, 2025 (initial publication), with correction made available online Where: Max Planck Institute for Biology of Ageing, Cologne, Germany; University of Gothenburg, Gothenburg, Sweden; University of Cambridge, Cambridge, UK Why: To correct an error in the surname of one author and provide clarity on the mechanisms driving inflammation How: The correction was made available online, with no changes to the study's findings. *Reporting by Nature.*