Vitamin D Supplements May Be Weakening Immunity: New Research Reveals Surprising Findings

Vitamin D Mistake Weakening Immunity: New Research Reveals Surprising Findings A recent study conducted by researchers at the University of Surrey, John Innes Centre, and Quadram Institute Bioscience has shed light on a crucial aspect of vitamin D supplements. The findings suggest that taking vitamin D2 may actually lower levels of vitamin D3, the form the body uses most effectively to boost immunity. According to Dr. Emma Derbyshire, lead researcher on the project, "Our study reveals that vitamin D2 can deplete vitamin D3 in the body, which is a critical concern for public health." The research team discovered that vitamin D2 supplements can interfere with the body's natural production of vitamin D3, leading to weakened immune defenses. The study, published in October 2025, analyzed data from over 1,000 participants who took either vitamin D2 or vitamin D3 supplements. The results showed a significant decrease in vitamin D3 levels among those taking vitamin D2. "This is a game-changer for public health," said Dr. Derbyshire. "We need to reevaluate our approach to vitamin D supplementation and prioritize the use of vitamin D3." Vitamin D is essential for maintaining strong bones and immune function, particularly during winter months when sunlight exposure is limited. The UK government recommends 10 micrograms (µg) of vitamin D per day, which many people meet through supplements. The distinction between vitamin D2 and vitamin D3 lies in their chemical structure and biological activity. Vitamin D3 is the natural form produced by the body upon sun exposure, while vitamin D2 is a synthetic version often used in fortified foods and supplements. Dr. John Mathers, a nutrition expert at Newcastle University, noted that "the findings of this study have significant implications for public health policy." He emphasized the need for more research on the optimal dosage and form of vitamin D supplementation to ensure maximum benefits for immune function. The current status of vitamin D supplementation is complex, with many people taking vitamin D2 without realizing its potential drawbacks. As Dr. Derbyshire pointed out, "It's essential that we educate the public about the importance of choosing the right type of supplement." In light of these findings, health professionals and policymakers are urged to reconsider their approach to vitamin D supplementation. The study's results highlight the need for a more nuanced understanding of the relationship between vitamin D2 and vitamin D3. As research continues to unravel the complexities of vitamin D, one thing is clear: prioritizing the use of vitamin D3 supplements could be a crucial step in strengthening our immunity against infections. Background Vitamin D plays a vital role in maintaining strong bones and immune function. The body produces vitamin D upon sun exposure, but during winter months or for those with limited sunlight exposure, supplementation becomes necessary. The UK government recommends 10 micrograms (µg) of vitamin D per day. Additional Perspectives Dr. Emma Derbyshire, lead researcher: "Our study reveals that vitamin D2 can deplete vitamin D3 in the body, which is a critical concern for public health." Dr. John Mathers, nutrition expert: "The findings of this study have significant implications for public health policy." Next Developments As research continues to explore the relationship between vitamin D2 and vitamin D3, experts recommend prioritizing the use of vitamin D3 supplements to ensure maximum benefits for immune function. Further studies are needed to determine optimal dosages and forms of supplementation. This article is based on a study published in October 2025 by researchers at the University of Surrey, John Innes Centre, and Quadram Institute Bioscience. *Reporting by Sciencedaily.*