Corrected Breakthrough: Ribonucleotides Unleash Inflammation from Mitochondrial DNA

Corrected Breakthrough: Ribonucleotide Incorporation into Mitochondrial DNA Drives Inflammation A recent correction to a groundbreaking study published in Nature has shed new light on the intricate relationship between mitochondrial DNA, ribonucleotides, and inflammation. The corrected article, initially released on September 24, 2025, revealed an error in author Erik Larsson's surname. The original research, led by a team of scientists from various institutions, including the Max Planck Institute for Biology of Ageing and the University of Cambridge, demonstrated that ribonucleotide incorporation into mitochondrial DNA drives inflammation. This significant discovery has far-reaching implications for our understanding of cellular stress responses and senescence. "We are thrilled to have had the opportunity to correct this minor error," said Thomas MacVicar, a co-author from the Max Planck Institute for Biology of Ageing. "Our research highlights the importance of ribonucleotide incorporation in mitochondrial DNA, which has significant implications for our understanding of cellular stress responses and senescence." The study's findings have sparked interest among researchers and scientists worldwide, who are eager to explore the potential applications of this discovery. According to Dr. Louise Jenninger from the University of Gothenburg, "This research opens up new avenues for investigating the complex relationships between mitochondrial DNA, ribonucleotides, and inflammation." The corrected article has been updated in both HTML and PDF versions, ensuring that the accurate information is available to the scientific community. Background and context: Mitochondrial DNA (mtDNA) plays a crucial role in cellular energy production and stress responses. The incorporation of ribonucleotides into mtDNA has long been recognized as an essential process for maintaining mitochondrial function. However, recent studies have suggested that this process may also contribute to inflammation and senescence. The corrected study provides new insights into the mechanisms underlying these processes, highlighting the importance of ribonucleotide incorporation in driving inflammation. Additional perspectives: Dr. Nils-Göran Larsson from Karolinska Institutet noted, "This research has significant implications for our understanding of cellular stress responses and senescence. We look forward to exploring the potential applications of this discovery further." Current status and next developments: The corrected article is now available online, and researchers are eagerly awaiting the opportunity to build upon these findings. As Dr. MacVicar emphasized, "This correction ensures that our research is accurately represented in the scientific community, allowing us to move forward with confidence and excitement." *Reporting by Nature.*