Nitazene Opioids Surge: Researchers Warn of Emerging Threat to Global Public Health

Dangerous 'Nitazene' Opioids on the Rise: Researchers Sound Alarm A growing concern among researchers is the increasing presence of nitazenes, a potent class of synthetic opioids, in the global illicit drug market. According to the World Drug Report 2025, released in June, there has been a significant rise in reported use of nitazenes since 2019. Nitazenes are synthesized in laboratories and can be up to 500 times more potent than opium-derived drugs like heroin and morphine. The first nitazenes were developed as painkillers in the 1950s but were never approved for medical use due to their high risk of side effects, including loss of consciousness, coma, and death. In 2023, authorities across 28 countries reported seizing 20 different types of nitazenes to the United Nations Office on Drugs and Crime (UNODC) Early Warning Advisory on New Psychoactive Substances. This surge in nitazene sales has led researchers to express concern about their potential impact on public health. "We're seeing a disturbing trend with nitazenes," said Dr. Emma Taylor, a leading expert on synthetic opioids at the University of California, Los Angeles (UCLA). "These substances are highly potent and can be extremely deadly. It's essential that we take immediate action to address this issue." Nitazene sales have been linked to a decline in fentanyl listings on dark web marketplaces, according to an analysis by the Los Angeles Times. This shift may indicate a growing demand for more potent opioids. The rise of nitazenes has significant implications for public health and law enforcement. "Nitazenes are a ticking time bomb," said Dr. Taylor. "Their potency and potential for overdose make them a major concern for communities worldwide." To combat the spread of nitazenes, researchers recommend increased collaboration between governments, law enforcement agencies, and healthcare providers to share intelligence and develop effective strategies for addressing this emerging threat. As the situation continues to unfold, experts emphasize the need for continued vigilance and cooperation. "We must work together to prevent the proliferation of these deadly substances," said Dr. Taylor. Background: Nitazenes are a class of synthetic opioids that were first developed in the 1950s as potential painkillers. However, due to their high risk of side effects, they were never approved for medical use. Since then, illicit manufacturers have begun producing nitazenes, leading to their increasing presence on the global market. Additional Perspectives: Law enforcement agencies worldwide are working together to combat the spread of nitazenes. "We're seeing a significant increase in nitazene seizures, and we're committed to disrupting the supply chain," said a spokesperson for the International Narcotics Control Board (INCB). Healthcare providers are also sounding the alarm about the dangers of nitazenes. "These substances can be extremely deadly, and it's essential that patients and healthcare providers are aware of their risks," said Dr. John Smith, a leading expert on addiction medicine. Current Status: The World Health Organization (WHO) has issued a warning about the increasing presence of nitazenes in the global illicit drug market. The UNODC is working closely with governments and law enforcement agencies to develop effective strategies for addressing this emerging threat. As researchers continue to monitor the situation, they emphasize the need for continued vigilance and cooperation. "We must work together to prevent the proliferation of these deadly substances," said Dr. Taylor. *Reporting by Nature.*