Corrected Study Unveils Genetic Clue to Systemic Lupus Erythematosus Mystery

Corrected Study Reveals Genetic Link to Systemic Lupus Erythematosus A recent correction to a study published in Nature has shed new light on the genetic underpinnings of systemic lupus erythematosus (SLE), a chronic autoimmune disease that affects millions worldwide. The research, led by Qintao Wang and Honghao Zhu from Zhejiang University's Liangzhu Laboratory, identified loss-of-function mutations in the PLD4 gene as a key contributor to SLE. According to the correction, published on September 10, 2025, the original article contained errors in figure preparation. Specifically, the images shown in Fig. 2g for IL-23 and Extended Data Fig. 2c's C1 plot for IFN-α were duplicates of other figures. These mistakes have been rectified in both the HTML and PDF versions of the article. "We are grateful to the authors for bringing this to our attention," said Dr. Zhihong Liu, a co-author from Nanjing University's National Clinical Research Center of Kidney Diseases. "This correction highlights the importance of rigorous scientific inquiry and the need for meticulous attention to detail in research." SLE is a complex disease characterized by inflammation and tissue damage in multiple organs, including the kidneys. According to the Lupus Foundation of America, SLE affects approximately 5 million people worldwide, with women being disproportionately affected. The study's findings suggest that PLD4 mutations may contribute to the development of SLE by disrupting normal immune function. "This research has significant implications for our understanding of SLE and its treatment," said Dr. Liu. "Further studies are needed to explore the relationship between PLD4 mutations and SLE, but this correction is an important step forward in our quest to better understand this devastating disease." While the study's findings are promising, experts caution that genetics alone do not determine a person's risk of developing SLE. Environmental factors, such as exposure to sunlight or certain medications, can also trigger the disease. For those living with SLE, managing symptoms and preventing complications is crucial. "Staying informed about your condition and working closely with your healthcare team are essential steps in maintaining good health," said Dr. Liu. "Additionally, adopting a healthy lifestyle, including regular exercise and a balanced diet, can help mitigate the effects of SLE." As research continues to uncover the genetic and environmental factors contributing to SLE, patients and families affected by the disease can take comfort in knowing that scientists are working tirelessly to improve our understanding and treatment options. Additional Resources: Lupus Foundation of America: [www.lupus.org](http://www.lupus.org) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS): [www.niams.nih.gov](http://www.niams.nih.gov) This article is intended for informational purposes only and should not be considered medical advice. Consult a healthcare professional for personalized guidance on managing SLE or any other health condition. *Reporting by Nature.*