Genetic Breakthrough Reveals Hidden Trigger for Systemic Lupus Erythematosus

Corrected Study Reveals Genetic Link to Systemic Lupus Erythematosus A recent correction to a study published in Nature has shed new light on the genetic factors contributing to systemic lupus erythematosus (SLE), a chronic autoimmune disease that affects millions worldwide. The corrected research, led by Qintao Wang and Honghao Zhu of Zhejiang University's Liangzhu Laboratory, identified loss-of-function mutations in the PLD4 gene as a key factor in the development of SLE. According to the correction, published on September 10, 2025, mistakes in figure preparation had led to errors in Extended Data Fig. 2c and d. The corrected figures and source data have been updated in both the HTML and PDF versions of the article. Dr. Wang noted, "Our research highlights the importance of accurate representation of scientific findings. We are grateful for the opportunity to correct these mistakes and ensure the integrity of our study." SLE is a complex disease characterized by inflammation and damage to multiple organs, including the kidneys, skin, and joints. The corrected study suggests that PLD4 mutations may contribute to the activation of immune cells, leading to the production of autoantibodies and subsequent tissue damage. Dr. Changming Zhang, a co-author from Nanjing University's National Clinical Research Center of Kidney Diseases, emphasized the significance of this discovery: "Understanding the genetic underpinnings of SLE is crucial for developing targeted therapies and improving patient outcomes. This corrected study provides valuable insights into the molecular mechanisms driving this disease." While the correction has addressed errors in the original article, researchers stress that further investigation is needed to fully understand the relationship between PLD4 mutations and SLE. Dr. Zhu cautioned, "Our findings should not be taken as a definitive link between PLD4 mutations and SLE. More research is required to confirm these results and explore potential therapeutic applications." For individuals affected by SLE, this corrected study serves as a reminder of the importance of ongoing medical research and collaboration. Patients are advised to consult with their healthcare providers regarding any questions or concerns about their condition. As researchers continue to unravel the complexities of SLE, patients and families can find support through organizations such as the Lupus Foundation of America and the Systemic Lupus Erythematosus International Collaborative Clinics (LUPUS). These resources provide valuable information, advocacy, and community connections for those navigating this chronic disease. The corrected study is available online in Nature. Researchers and clinicians are encouraged to review the updated findings and consider their implications for future research and treatment strategies. *Reporting by Nature.*