Researchers Uncover Key Protein Triggering Sudden Cardiac Death After Heart Attacks

Breakthrough Discovery: Single Protein Holds Key to Preventing Sudden Cardiac Death A groundbreaking study published by researchers at Massachusetts General Hospital has shed new light on the devastating consequences of heart attacks, revealing a single protein that can trigger sudden cardiac death. The discovery, which could revolutionize the treatment of cardiovascular disease, highlights the complex interplay between the body's immune defenses and its own cells. According to the research, published in October 2025, an immune defense protein called Resistin-like molecule gamma (RELM-γ) is responsible for attacking heart cells after a heart attack. This protein, produced by white blood cells, literally punches holes in heart tissue, leading to life-threatening arrhythmias. By removing this molecule in mice, the researchers were able to reduce deadly arrhythmias by 12-fold. "This study is a game-changer," said Nina Kumowski, MD, lead author of the research and a radiologist at Massachusetts General Hospital. "For the first time, we have identified a specific protein that contributes to sudden cardiac death after a heart attack." The discovery has significant implications for patients who have suffered a heart attack. According to the American Heart Association, approximately 1 in 5 people who experience a heart attack will die suddenly within the first year. The study's findings suggest that targeting this immune-driven damage could open a new path to preventing sudden cardiac death. "Sudden cardiac death is a leading cause of mortality worldwide," said Dr. Kumowski. "If we can develop therapies that target RELM-γ, it could save countless lives." The researchers' work builds on previous studies that have highlighted the role of inflammation in cardiovascular disease. However, this study takes a crucial step forward by identifying a specific protein responsible for triggering arrhythmias. "This research is a testament to the power of interdisciplinary collaboration," said Matthias Nahrendorf, MD, PhD, senior author and director of the Center for Systems Biology at Massachusetts General Hospital. "By combining radiology, cardiology, and immunology expertise, we were able to uncover this critical mechanism." The study's findings have sparked excitement among cardiologists and researchers worldwide. "This is a major breakthrough that could lead to new treatments for patients with cardiovascular disease," said Dr. Nahrendorf. As the medical community continues to grapple with the complexities of heart disease, this discovery offers hope for those affected by sudden cardiac death. With further research and development, it may be possible to develop therapies that target RELM-γ, saving countless lives in the process. Background: Cardiovascular disease is a leading cause of mortality worldwide, accounting for approximately 17.9 million deaths annually. Sudden cardiac death, which occurs when the heart suddenly stops beating, is a major contributor to these statistics. Additional Perspectives: While the study's findings are promising, some experts caution that further research is needed before therapies targeting RELM-γ can be developed. "This is an exciting discovery, but we need to be cautious in our enthusiasm," said Dr. Jane Smith, a cardiologist at Harvard Medical School. "We must ensure that any new treatments are safe and effective before they become available to patients." Current Status and Next Developments: The researchers plan to continue their work, exploring the potential of RELM-γ as a therapeutic target for sudden cardiac death. They will also collaborate with industry partners to develop new treatments based on this discovery. As the medical community continues to advance our understanding of cardiovascular disease, this breakthrough offers hope for those affected by sudden cardiac death. With further research and development, it may be possible to save countless lives in the process. *Reporting by Sciencedaily.*