Scientists Uncover Brain's Hidden Rhythm Linked to Alzheimer's Onset

Scientists Uncover Hidden Brain Pulse Linked to Alzheimer's LOS ANGELES, CA - October 14, 2025 - Researchers at the Keck School of Medicine of USC have made a groundbreaking discovery that may revolutionize our understanding of aging and Alzheimer's disease. By capturing the brain's hidden heartbeat using advanced MRI technology, scientists have identified a microscopic blood vessel pulse that grows stronger with age and vascular risk. According to Dr. Guo, lead author of the study, "Our novel MRI technique allows us to map cerebral microvascular volumetric pulsatility across cortical and white matter regions for the first time." This non-invasive method uses 7T MRI technology to measure the tiny pulsations of blood vessels in the brain, providing a new key to understanding how circulation changes contribute to neurodegenerative diseases. The study's findings suggest that these microscopic pulses disrupt the brain's waste-clearing systems, potentially leading to Alzheimer's and other age-related cognitive decline. "Our research highlights the importance of vascular health in maintaining healthy brain function," said Dr. Guo. "This discovery may explain why some people are more susceptible to Alzheimer's disease." The study's background is rooted in the understanding that aging and vascular risk factors contribute to changes in blood vessel pulsatility. As we age, our brains undergo natural changes, including a decline in cognitive function and an increase in neurodegenerative diseases such as Alzheimer's. Dr. Stevens, director of the Mark and Mary Stevens Neuroimaging and Informatics Institute at USC, emphasized the significance of this research: "This breakthrough has the potential to transform our understanding of aging and Alzheimer's disease. By identifying a biomarker for vascular health, we may be able to develop new treatments or prevention strategies." The study's implications extend beyond medical research, with potential applications in fields such as neurology, gerontology, and public health. As Dr. Guo noted, "Our findings have the potential to improve our understanding of how lifestyle choices and environmental factors impact brain health." Currently, researchers are working to validate these results using larger cohorts and exploring the potential for early detection and intervention. The study's authors believe that this discovery may lead to new therapeutic approaches, such as improving vascular function or developing targeted treatments. As scientists continue to unravel the mysteries of the human brain, this groundbreaking research offers a promising new avenue for understanding and combating Alzheimer's disease. With its potential to revolutionize our understanding of aging and brain health, this study is a significant step forward in the quest to improve human well-being. Sources: Keck School of Medicine of USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) Dr. Guo, lead author Dr. Stevens, director of Stevens INI Related Research: Recent studies have highlighted the importance of vascular health in maintaining cognitive function. Researchers are exploring the potential for early detection and intervention using biomarkers such as blood vessel pulsatility. Note to editor: For more information on this study or to schedule an interview with Dr. Guo, please contact [insert contact information]. *Reporting by Sciencedaily.*