Scientists at Johns Hopkins Discover Alzheimer's Spread Path: Toxin-Carrying Nanotubes

Tiny Brain Nanotubes Found by Johns Hopkins May Spread Alzheimer's In a groundbreaking discovery, scientists at Johns Hopkins Medicine have identified microscopic nanotube channels that neurons use to transfer toxic molecules, potentially contributing to the spread of Alzheimer's disease. According to research published on October 16, 2025, these tiny tubes, called intercellular nanotubes, play a crucial role in clearing waste from brain cells but can also facilitate the transmission of harmful proteins like amyloid-beta. The study, led by researchers at Johns Hopkins Medicine, used genetically modified mice and advanced imaging tools to visualize the intricate networks of nanotubes within the brain. The findings suggest that an overabundance of these tubes may be linked to the development of Alzheimer's disease. "Our research shows that intercellular nanotubes are not just passive conduits for waste removal but can also actively contribute to the spread of toxic proteins," said Dr. Minhyeok Chang, lead author of the study. The discovery has significant implications for our understanding of Alzheimer's disease and potential therapeutic approaches. "This finding opens up new avenues for research into the mechanisms underlying Alzheimer's disease and may ultimately lead to the development of novel treatments that target these nanotube channels," said Dr. Chang. Background on Alzheimer's disease is essential to understanding this discovery. Alzheimer's is a progressive neurological disorder characterized by the accumulation of amyloid-beta plaques and tau tangles in the brain, leading to memory loss, cognitive decline, and eventually death. While the exact causes of Alzheimer's remain unknown, research has shown that genetic mutations, age-related changes, and environmental factors all contribute to its development. The study's findings have sparked interest among experts in the field. "This research highlights the complex interplay between brain cells and their environment, which is crucial for understanding how diseases like Alzheimer's arise," said Dr. David M. Holtzman, a leading expert on neurodegenerative diseases at Washington University School of Medicine. The study's results also raise questions about the potential role of nanotube channels in other neurological disorders. "Further research is needed to determine whether these findings have broader implications for our understanding of brain function and disease," said Dr. Chang. As researchers continue to explore the intricacies of intercellular nanotubes, they hope to develop novel therapeutic strategies that target these channels. "By controlling the formation and function of nanotube channels, we may be able to prevent or slow the progression of Alzheimer's disease," said Dr. Chang. The study was supported by the National Institutes of Health (NIH) and has significant implications for our understanding of brain function and disease. As researchers continue to unravel the mysteries of intercellular nanotubes, they may uncover new avenues for treating devastating neurological disorders like Alzheimer's disease. Sources: Johns Hopkins Medicine National Institutes of Health (NIH) Washington University School of Medicine Related Stories: "Understanding Alzheimer's Disease: A Guide to the Latest Research" "The Role of Genetics in Alzheimer's Disease" "New Therapies on the Horizon for Alzheimer's Patients" *Reporting by Sciencedaily.*