Altering Body Rhythms May Shield the Brain from Alzheimer's Damage

Researchers at Washington University School of Medicine in St. Louis have discovered that altering the body's natural rhythm can help protect the brain from Alzheimer's damage. According to a study published in Nature Aging, disrupting communication between the body's internal clock and the brain may limit neurodegeneration in Alzheimer's disease. The study, led by Erik Musiek, MD, PhD, found that turning off a circadian protein in mice raised levels of NAD, a molecule that helps protect the brain, and reduced the buildup of tau, a protein associated with Alzheimer's disease. "Our findings suggest that adjusting the body's clock may one day help prevent neurodegeneration," Musiek said in a statement. The researchers explored how changes in the circadian system affect brain health and memory in mouse models of Alzheimer's disease. They discovered that interfering with the body's internal clock boosted brain-protective molecules and reduced signs of Alzheimer's in mice. The study's findings hint that timing may play a powerful role in keeping the brain healthy. Alzheimer's disease is a complex condition characterized by the progressive loss of memory and cognitive function. The disease affects millions of people worldwide, and current treatments are largely ineffective in halting its progression. The discovery of a potential link between the body's internal clock and Alzheimer's disease offers new hope for the development of effective treatments. Musiek and his team are now working to understand the underlying mechanisms of the body's internal clock and its impact on brain health. "We are excited about the potential of this research to lead to new therapeutic strategies for Alzheimer's disease," Musiek said. The study's findings have significant implications for our understanding of the relationship between the body's internal clock and brain health. Further research is needed to confirm the results and explore the potential of this approach for preventing or treating Alzheimer's disease. The study was published in Nature Aging on November 1, 2025.