Body Rhythm Reset May Shield Brain from Alzheimer's Onset

Researchers at Washington University School of Medicine in St. Louis have discovered that altering the body's natural rhythm can help protect the brain from Alzheimer's damage. According to a study published in Nature Aging, disrupting communication between the body's internal clock and the brain could help limit neurodegeneration in Alzheimer's disease. The study, led by Erik Musiek, MD, PhD, found that turning off a circadian protein in mice raised levels of NAD, a molecule that helps protect the brain, and reduced the buildup of harmful tau protein, a hallmark of Alzheimer's disease. The researchers observed that the mice with altered circadian rhythms showed improved cognitive function and reduced signs of Alzheimer's. "We were surprised by the significant impact that altering the body's internal clock had on brain health and memory," Musiek said. "Our findings suggest that timing may play a powerful role in keeping the brain healthy, and that manipulating the body's circadian system could be a potential therapeutic strategy for preventing neurodegeneration in Alzheimer's disease." The study's findings are significant because they provide new insights into the relationship between the body's internal clock and brain health. Previous research has shown that disruptions to the circadian system can contribute to a range of health problems, including obesity, diabetes, and cardiovascular disease. The study's results have implications for the development of new treatments for Alzheimer's disease. Currently, there is no cure for the disease, and existing treatments are primarily focused on managing symptoms. However, the discovery of a potential therapeutic strategy for preventing neurodegeneration in Alzheimer's disease offers new hope for patients and their families. The researchers plan to continue studying the relationship between the body's internal clock and brain health, with the goal of developing new treatments for Alzheimer's disease. They are also exploring the potential of manipulating the body's circadian system to prevent other neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. The study's findings are a testament to the importance of continued research into the causes and treatment of Alzheimer's disease. As the global population ages, the number of people affected by Alzheimer's disease is expected to increase, making the development of effective treatments a pressing public health priority. The study was funded by the National Institutes of Health and the Alzheimer's Association. The researchers hope that their findings will contribute to the development of new treatments for Alzheimer's disease and improve the lives of patients and their families.