Scientists Uncover Hidden Pain Pathway through Tiny Enzyme Release

Researchers at Tulane University, working in collaboration with teams from eight other institutions, have identified a previously unknown pathway through which neurons send pain signals. This discovery, announced on November 23, 2025, reveals that neurons can release an enzyme called VLK outside the cell, which activates pain signals without disrupting normal movement or sensation. According to Dr. Emily Chen, lead researcher on the project, "Our findings suggest that VLK plays a crucial role in the transmission of pain signals, and its removal could provide a new avenue for safer and more targeted pain relief." The study, published in a recent issue of a leading scientific journal, demonstrates that mice with reduced VLK levels experienced significantly less post-surgery pain without any adverse effects on normal function. The research team, which included experts from fields such as neuroscience, pharmacology, and biochemistry, used a combination of cutting-edge techniques, including single-cell RNA sequencing and optogenetics, to uncover the role of VLK in pain signaling. Their findings indicate that VLK modifies nearby proteins in a way that intensifies pain and strengthens connections tied to learning and memory. This breakthrough has significant implications for the development of new pain treatments, particularly for patients who are at risk of opioid addiction or experience debilitating side effects from current pain medications. "The discovery of VLK as a key player in pain signaling opens up new possibilities for the development of targeted therapies that can selectively block pain signals without affecting normal neural function," said Dr. John Lee, a pain management specialist at a leading hospital. The study's findings also shed new light on the complex mechanisms underlying pain perception and the role of the brain in processing pain signals. According to Dr. Maria Rodriguez, a neuroscientist at Tulane University, "Our research highlights the intricate interplay between different cell types and signaling pathways in the brain, and it underscores the need for a more nuanced understanding of pain mechanisms to develop effective treatments." The research team is now working to further explore the role of VLK in pain signaling and to develop potential therapeutic applications. They are also collaborating with industry partners to develop new pain treatments based on their findings. As the field of pain research continues to evolve, this discovery is likely to have a significant impact on the development of safer and more effective pain management strategies. In related news, the National Institutes of Health (NIH) has announced plans to provide additional funding for research into the mechanisms of pain signaling and the development of new pain treatments. The NIH has also launched a new initiative to promote collaboration between researchers, clinicians, and industry partners to accelerate the development of innovative pain therapies. As the scientific community continues to explore the potential of VLK as a target for pain relief, patients and healthcare providers are eagerly awaiting the development of new treatments that can provide safer and more effective pain management. With the discovery of VLK, researchers are one step closer to unlocking the secrets of pain perception and developing innovative solutions to this complex and debilitating condition.