Nature Corrects a Killer Mistake: Caspase-8's Role in Cell Death Revealed

A correction was made to a study published in the journal Nature on November 13, 2019, regarding the activity of caspase-8 and its role in determining plasticity between cell death pathways. The correction was necessary due to a figure preparation error in the original article. The error involved an inadvertent duplicate of a figure in the lower-right panel of Extended Data Fig. 7e, which showed the Casp8 cKI Mlkl KO vav.cre dot plot. The figure legend to Extended Data Fig. 7eg also required correction, and the revised figure is now available as Supplementary Information alongside this amendment. According to the correction, the figure legend should read: "Flow cytometry analysis of bone marrow (e), mesenteric lymph node (f), and spleen (g) cells from the mice in d." The study, which was conducted by researchers at Genentech, aimed to understand the role of caspase-8 in determining plasticity between cell death pathways. The research has significant implications for our understanding of cell death and immune response, and could potentially lead to new treatments for various diseases. Dr. Kim Newton, one of the authors of the study, stated that the correction was necessary to ensure the accuracy and reliability of the research. "We take all corrections seriously and are committed to ensuring the integrity of our research," she said. The study's findings have been widely cited in the scientific community, and the correction will not affect the overall conclusions of the research. However, it is essential to correct the error to maintain the credibility and trustworthiness of the study. The correction serves as a reminder of the importance of accuracy and attention to detail in scientific research. It also highlights the ongoing efforts of researchers to refine and improve their findings, ensuring that the scientific community has access to reliable and trustworthy information. The study's findings have significant implications for our understanding of cell death and immune response, and could potentially lead to new treatments for various diseases. The correction will not affect the overall conclusions of the research, and the study remains a valuable contribution to the field of cell death and immune response research. The researchers at Genentech continue to work on refining their findings and exploring new avenues of research. The correction serves as a reminder of the importance of ongoing research and the need for continued refinement and improvement in scientific inquiry.