Researchers Correct Mistake in Groundbreaking Weight Loss Study

Researchers at the NYU Grossman School of Medicine have made a correction to their study on cysteine-deficiency-associated rapid weight loss, which was published in the journal Nature on May 21, 2025. The correction involves a copy-paste error in Extended Data Fig. 2f,g, where the muscle HE panel for Day 3 Het No Cys was identical to the Day 7 KO Ctrl diet, and the Day 3 KO Ctrl panel was identical to the Day 7 KO No Cys. The figure has now been updated with the correct panels in both the HTML and PDF versions of the article. According to the correction notice, the error did not affect the conclusions of the figure or the overall paper. The study, which was a collaborative effort between researchers from the Department of Cell Biology and the Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine, aimed to unravel the mechanisms behind cysteine-deficiency-associated rapid weight loss. "We are pleased to have made this correction and to have clarified the figure," said Alan Varghese, one of the authors of the study. "Our research continues to shed light on the complex relationships between fat metabolism, metabolomics, and mitochondria, and we look forward to continuing to explore these topics in the future." The study's findings have significant implications for our understanding of how cysteine deficiency can lead to rapid weight loss. Cysteine is an essential amino acid that plays a critical role in various bodily functions, including the synthesis of proteins and the maintenance of healthy mitochondria. The correction notice was published in the journal Nature on May 21, 2025, and is available online. The study's authors have confirmed that the correction does not affect the overall conclusions of the paper and that the research continues to be a valuable contribution to the field of fat metabolism and metabolomics. As researchers continue to explore the complex relationships between cysteine deficiency and rapid weight loss, this correction serves as a reminder of the importance of attention to detail in scientific research. By addressing errors and clarifying figures, researchers can ensure that their findings are accurate and reliable, and that the scientific community can build on their work with confidence.