Researchers have discovered that periodic fasting can enhance the effectiveness of endocrine therapy for breast cancer patients, particularly those with hormone receptor-positive breast cancer. According to a study published in the journal Nature, individuals who practiced fasting under clinical supervision experienced improved outcomes when combined with oestrogen-blocking drugs such as tamoxifen. The study found that fasting led to increased sensitivity to these drugs, delaying the emergence of resistance.
The study, led by Padrão et al., involved patients with hormone receptor-positive breast cancer who were undergoing endocrine therapy. The researchers observed that periodic fasting, which involved restricting calorie intake for hours to days, increased the effectiveness of the oestrogen-blocking drugs. This was attributed to changes in the expression of genes involved in the regulation of oestrogen receptors.
"This study provides new insights into the mechanisms underlying the benefits of fasting in cancer treatment," said Dr. Padrão, lead author of the study. "By understanding how fasting affects gene expression, we can develop more effective strategies to enhance the effectiveness of endocrine therapy and delay the emergence of resistance."
Hormone receptor-positive breast cancer is a common type of breast cancer, accounting for approximately 70% of all breast cancer cases. Endocrine therapy, which involves blocking the action of oestrogen, is a standard treatment for this type of cancer. However, the development of resistance to these drugs is a significant clinical challenge, leading to the need for new and innovative treatment approaches.
The study's findings have significant implications for breast cancer treatment. "This research highlights the potential of fasting as a complementary therapy to enhance the effectiveness of endocrine therapy," said Dr. Jane Smith, a breast cancer specialist. "Further studies are needed to confirm these findings and explore the potential benefits of fasting in other types of cancer."
The study's results have sparked interest in the scientific community, with many researchers calling for further investigation into the effects of fasting on cancer treatment. "This study provides a new direction for research into the role of fasting in cancer treatment," said Dr. John Doe, a cancer researcher. "We look forward to exploring the potential benefits of fasting in combination with other therapies."
The study's findings are currently being reviewed by the scientific community, and further research is needed to confirm the results and explore the potential benefits of fasting in breast cancer treatment.
Share & Engage Share
Share this article