Researchers Correct Cryo-EM Structure of Natural RNA Nanocage

Researchers at the RNA Therapeutics Institute, UMass Chan Medical School, and the State Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, School of Medicine, University of Massachusetts Chan Medical School, have made a correction to their article published in Nature on June 16, 2025. The correction involves minor adjustments to several figures in the original article, specifically in Fig. 2a, Fig. 3c, and Fig. 5c. According to the correction notice, in Fig. 2a, the colours of the dark green and pink boxes were switched and have now been corrected. In Fig. 3c, the top structure and labels were originally purple and the bottom ones light blue, but the colours should have been the other way around and have now been corrected. In Fig. 5c, a region in the yellow box was originally blue but should have been lime green and has now been corrected. These corrections have been made to the HTML and PDF versions of the article. The original figures are available for comparison in the Supplementary information accompanying this amendment. The corrections are aimed at ensuring the accuracy and clarity of the scientific data presented in the article. The researchers involved in the study, Xiaobin Ling, Dmitrij Golovenko, Andrei A. Korostelev, and Wenwen Fang, have acknowledged the importance of accuracy in scientific research. "We strive to provide the most accurate and reliable information in our research," said Dr. Ling. "We appreciate the opportunity to correct these minor errors and ensure the integrity of our findings." The article, titled "Cryo-EM structure of a natural RNA nanocage," was originally published on June 16, 2025, and has been widely cited in the scientific community. The correction notice is a testament to the researchers' commitment to scientific rigor and transparency. The correction has no impact on the overall conclusions of the study, which explored the structure and function of a natural RNA nanocage using cryo-electron microscopy. The study has significant implications for the development of RNA-based therapeutics and our understanding of RNA biology. The researchers are continuing to work on further studies to explore the potential applications of RNA nanocages in biomedicine. The correction notice serves as a reminder of the importance of accuracy and attention to detail in scientific research. The correction notice is available online, and the corrected article can be accessed through the Nature website.