Generally speaking, the higher the degree of information restoration of a vaccine to a virus, the greater its potential efficacy. The virus itself is the most authentic vaccine, such as the varicella-zoster virus, which provides lifelong immunity after a single infection. However, viruses also evolve mechanisms to evade immune surveillance during their long evolutionary history, such as evading the immune system's pursuit by frequently changing disguises through high mutability.
VPNVax: Crafting enhanced viral structure in vaccines through polymer restructuring