Extraordinary medical cases, even the grisly and disturbing ones, offered a unique perspective on the human condition in 2025, providing a break from everyday concerns and highlighting the resilience and sometimes unfortunate vulnerabilities of the human body. This year saw a range of unusual clinical conditions, marking medical firsts and ultra-rare presentations, alongside the consequences of questionable lifestyle choices.

The selection of the top five cases was based on a combination of editorial judgment, considering the rarity of the condition, the severity of the presentation, and the lessons learned for the medical community and the public. These cases serve as reminders of the complexities of human health and the importance of informed decision-making.