MIT scientists have discovered a groundbreaking method to rejuvenate aging immune systems. The innovative approach, unveiled December 29, 2025, uses mRNA to transform the liver into a temporary immune booster. This breakthrough could significantly improve the health and longevity of older adults.

Researchers at MIT developed the mRNA-based therapy. It effectively restores T-cell production, a function that typically declines with age. The treatment involves delivering mRNA to the liver, prompting it to generate immune-boosting signals usually produced by the thymus. In trials, older mice treated with this method showed enhanced T-cell production and a stronger response to vaccines and cancer therapies.

The discovery has major implications for the pharmaceutical industry. Experts predict accelerated development of similar mRNA-based immunotherapies. The technology could lead to new treatments for age-related immune deficiencies.

A weakened immune system in older adults increases susceptibility to infections. This new approach offers a potential solution by revitalizing the body's natural defenses.

MIT researchers are now focused on human trials. They aim to refine the mRNA delivery system and assess long-term effects. The team anticipates the therapy could be available within the next five to seven years.