The finding was particularly notable because ADAMTS2 also emerged as a top gene in an independent study of White individuals, suggesting a common underlying mechanism in Alzheimer's development, researchers said. This discovery opens potential avenues for new treatment strategies targeting this shared biological pathway.

Alzheimer's disease affects African Americans at approximately twice the rate of White or European-ancestry individuals in the United States. Researchers have long sought to understand the genetic and environmental factors contributing to this disparity. The identification of ADAMTS2 as a potentially universal Alzheimer's gene represents a significant step forward.

The study, published on January 1, 2026, highlights the importance of including diverse populations in genetic research. By studying African American brain tissue, researchers were able to pinpoint a gene that might have been overlooked in studies focused solely on White populations. This underscores the need for broader representation in research to ensure that findings are applicable to all individuals affected by the disease.

The implications of this research extend beyond genetics. Understanding the role of ADAMTS2 in Alzheimer's could lead to the development of targeted therapies that address the underlying biological processes driving the disease. This could potentially benefit individuals of all racial and ethnic backgrounds.

Further research is needed to fully elucidate the function of ADAMTS2 in Alzheimer's and to determine how it interacts with other genetic and environmental factors. Scientists are currently working to develop cellular and animal models to study the gene in more detail. The hope is that this research will ultimately lead to new and more effective treatments for Alzheimer's disease.