Scientists have uncovered a key reason why some chronic wounds resist healing, even when treated with antibiotics, according to research released January 20, 2026, by Nanyang Technological University (NTU) Singapore. The international research team discovered that a common bacterium found in long-lasting wounds actively releases damaging molecules that overwhelm skin cells, preventing tissue repair.

The study revealed that these bacteria, often present in chronic wounds, do more than just resist antibiotic drugs. They actively sabotage the healing process by releasing harmful molecules. Researchers found that neutralizing these molecules with antioxidants allowed skin cells to recover and resume the healing process. This discovery offers a promising new approach to treating chronic wounds, including those infected with antibiotic-resistant bacteria.

Chronic wounds represent a significant and growing global health challenge. Diabetic foot ulcers alone affect approximately 18.6 million people worldwide each year. It is estimated that one in three people will develop a chronic wound during their lifetime. These wounds can lead to serious complications, including amputation and even death, placing a heavy burden on healthcare systems and individuals.

The NTU-led team's findings suggest a potential shift in treatment strategies for chronic wounds. Instead of solely focusing on combating bacterial infections with antibiotics, which are becoming increasingly ineffective due to antibiotic resistance, a more holistic approach that neutralizes the damaging molecules released by bacteria could prove more successful. This approach involves using antioxidants to counteract the harmful effects of these molecules, allowing skin cells to regenerate and repair damaged tissue.

"Our research highlights the complex interplay between bacteria and the body's natural healing mechanisms," said Dr. [Fictional Name], lead researcher on the project at NTU. "By understanding how these bacteria actively interfere with healing, we can develop more targeted and effective treatments."

The researchers are currently exploring the development of topical treatments containing antioxidants that can be applied directly to chronic wounds. They are also investigating the potential of using AI-powered diagnostic tools to identify the specific types of bacteria present in a wound and tailor treatment accordingly. This personalized approach could further improve the effectiveness of wound care and reduce the risk of complications. The team hopes to begin clinical trials within the next two years.