Global DNA Study Reveals Hidden Threat in Diabetic Foot Infections

A global DNA study revealed that diabetic foot infections are fueled by a diverse range of E. coli strains, many exhibiting antibiotic resistance, challenging the idea of a single cause. The research, conducted by scientists at King's College London, uncovered new clues about why these infections can become severe and difficult to treat. The findings were published January 20, 2026.

The worldwide DNA analysis showed an unexpected level of diversity in the E. coli bacteria taken from infected wounds around the world, according to Science Daily. Researchers found that multiple types of E. coli appear able to thrive in diabetic foot ulcers, helping explain why infections can worsen.

Diabetic foot infections are a significant concern, particularly in developing nations, and disproportionately affect vulnerable populations. These infections can lead to amputations worldwide. The discovery of multiple antibiotic-resistant strains underscores the need for tailored treatment strategies to combat these infections.

By analyzing the DNA of E. coli bacteria, researchers found many strains carrying genes linked to antibiotic resistance and aggressive disease. This suggests that rather than a single dangerous strain, multiple types of E. coli are able to thrive in diabetic foot ulcers.