A published Nature article is under scrutiny. The journal issued an expression of concern regarding a PCR gel image in a 1998 paper. The article, "Editorial Expression of Concern: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM," is now being reviewed.
The concern focuses on Figure 4a of the paper. Specifically, the bottom halves of lanes B3 and B1 appear strikingly similar. The article was published online October 1, 1998. The authors are affiliated with institutions in the US, Italy, and Austria.
The expression of concern raises questions about the data's integrity. This could impact the understanding of SAP's role in X-linked lymphoproliferative disease. Nature is urging readers to consider this concern when interpreting the findings.
The 1998 study investigated how SAP, a protein linked to X-linked lymphoproliferative disease, regulates immune cell signaling. This disease causes severe immune system dysfunction. Further investigation is needed to determine the extent of the issue. The journal has not announced further steps, but an investigation is likely.
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