In a small clinical trial, customized mRNA vaccines against high-risk skin cancers appeared to reduce the risk of cancer recurrence and death by nearly 50 percent over five years when compared with standard treatment alone, Moderna and Merck announced this week. The two pharmaceutical companies have collaborated on the experimental cancer vaccine, called intismeran autogene (mRNA-4157 or V940).
The companies have so far only reported the top-line results in a press release. However, the results align closely with previous, more detailed analyses from the trial, which examined rates of recurrence and death at earlier time points, specifically at two years and three years after the treatment.
The ongoing Phase 2 trial included 157 patients who were diagnosed with stage 3 or stage 4 melanoma and were at high risk of having it recur after surgical removal. All patients received a standard treatment.
More data from the trial, a Phase 2 trial, will soon be presented at a medical conference, the companies said. A Phase 3 trial is also underway, with enrollment complete.
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