In a correction issued today, Nature addressed an error in the original publication of the article "Rewiring an olfactory circuit by altering cell-surface combinatorial code," which appeared online on November 19, 2025. The correction involves Figure 1h of the original article, where the bottom three panels in the klg RNAi column were found to be duplicates of images from Figure 1c.
The journal has updated both the HTML and PDF versions of the article to reflect the corrected Figure 1h. The error, while seemingly minor, is significant in the context of scientific research, where accurate representation of data is paramount. The study, authored by Cheng Lyu, Zhuoran Li, Chuanyun Xu, Jordan Kalai, and Liqun Luo from Stanford University's Department of Biology and Howard Hughes Medical Institute, explores how manipulating cell-surface proteins can redirect neural circuits in the olfactory system. This type of research holds potential implications for understanding brain development and potentially treating neurological disorders.
According to Nature, the correction ensures the integrity of the published findings. The original article detailed how researchers altered the combinatorial code of cell-surface proteins to effectively rewire an olfactory circuit. This involved intricate experiments and detailed imaging, making the accuracy of each figure crucial for interpreting the results. The olfactory system, responsible for our sense of smell, serves as a model for understanding how neural circuits are formed and modified. The implications of this research extend beyond the realm of olfaction, potentially informing strategies for neural repair and regeneration.
The authors, affiliated with Stanford University, have not yet released a statement regarding the correction. Liqun Luo, the corresponding author, can be reached for further inquiries. The field of neural circuit research is closely watched by both the scientific community and the broader public, given its potential to unlock new treatments for neurological conditions and enhance our understanding of the brain. This correction underscores the importance of rigorous peer review and the commitment to accuracy in scientific publishing.
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