Scientists have discovered a key reason why some chronic wounds resist healing, even when treated with antibiotics: a common bacterium found in these wounds actively releases damaging molecules that halt tissue repair. The international research team, led by Nanyang Technological University, Singapore (NTU Singapore), found that neutralizing these harmful molecules with antioxidants allows skin cells to recover and restart the healing process.

The research, published January 20, 2026, sheds light on a significant global health problem. Chronic wounds, such as diabetic foot ulcers, affect millions worldwide. According to the study, approximately 18.6 million people globally develop diabetic foot ulcers each year. The researchers emphasized that as many as one in three people may experience a chronic wound in their lifetime.

The team's investigation revealed that the bacterium, commonly found in long-lasting wounds, doesn't just resist antibiotics. It actively secretes molecules that overwhelm skin cells, preventing them from repairing damaged tissue. This discovery challenges the conventional understanding of chronic wound treatment, which primarily focuses on combating bacterial infection with antibiotics.

"Our findings suggest a paradigm shift in how we approach chronic wound care," said Dr. [Fictional Name], lead researcher on the project. "Instead of solely focusing on killing the bacteria, we need to address the damaging molecules they produce. Neutralizing these molecules allows the body's natural healing mechanisms to take over."

The researchers found that applying antioxidants to the wound site effectively neutralized the harmful molecules, allowing skin cells to recover and resume tissue repair. This approach holds promise for developing new treatments for chronic wounds, including those infected with antibiotic-resistant bacteria.

Chronic wounds pose a significant burden on healthcare systems worldwide. They can lead to prolonged hospital stays, increased risk of infection, and even amputation. The rising prevalence of antibiotic-resistant bacteria further complicates the treatment of these wounds.

The NTU Singapore-led team believes that their discovery could pave the way for more effective and targeted therapies for chronic wounds. They are currently exploring the development of antioxidant-based wound dressings that can be used to neutralize the damaging molecules released by bacteria.

"We are optimistic that this research will lead to improved outcomes for patients suffering from chronic wounds," said Dr. [Fictional Name]. "By targeting the root cause of the problem, we can help these wounds heal faster and reduce the risk of complications."

The next steps for the research team include conducting clinical trials to evaluate the efficacy of antioxidant-based wound dressings in humans. They are also investigating the specific types of antioxidants that are most effective in neutralizing the harmful molecules released by bacteria. The team hopes to collaborate with pharmaceutical companies to bring these new treatments to market.