A published Nature article is under scrutiny. The journal issued an "Editorial Expression of Concern" regarding a figure in a 1998 paper. The article, titled "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM," faces questions about image integrity.

The concern focuses on Figure 4a, specifically lanes B3 and B1. Editors noted a high degree of similarity between the bottom halves of these lanes. The paper, published online October 1, 1998, investigated the role of the SAP protein in X-linked lymphoproliferative disease. The research was conducted by scientists at multiple institutions, including Beth Israel Deaconess Medical Center and Harvard Medical School.

The expression of concern raises questions about the reliability of the data presented in Figure 4a. This could impact the interpretation of the study's findings. The authors have not yet issued a public statement.

X-linked lymphoproliferative disease (XLP) is a rare immune deficiency. It makes individuals highly susceptible to Epstein-Barr virus (EBV) infection. Understanding the underlying mechanisms of XLP is crucial for developing effective treatments.

Nature's editors are likely investigating the matter further. The journal may request additional information from the authors. The outcome of this investigation could range from a correction to a retraction of the paper. The scientific community awaits further developments.