A correction has been issued for a research article published in Nature on January 14, 2026, concerning polyamine-dependent metabolic shielding and its influence on alternative splicing. The original article, which explored the intricate relationship between cellular metabolism and RNA processing, contained an error in Figure 1g.

Specifically, three labels on the right-hand side of Figure 1g, which initially read "24 h," should have been labeled "SAT1," "SMARCA1," and "ACTB," respectively. The correction addresses a mislabeling issue within a visual representation of experimental data related to the study's findings on alternative splicing, a fundamental process in gene expression where different combinations of exons within a pre-mRNA transcript can be joined, leading to multiple mRNA isoforms.

The authors, a collaborative team from the Center for Cooperative Research in Biosciences (CIC bioGUNE) in Derio, Spain, including Amaia Zabala-Letona, Mikel Pujana-Vaquerizo, and others, investigated how polyamines, essential metabolites involved in cell growth and differentiation, mediate metabolic shielding to regulate alternative splicing. Their research delved into the complex interplay between metabolomics and RNA biology, revealing potential therapeutic targets for diseases linked to aberrant splicing patterns.

Alternative splicing is a crucial mechanism for increasing protein diversity from a limited number of genes. Errors in this process have been implicated in various diseases, including cancer and neurological disorders. Understanding the factors that regulate alternative splicing, such as the metabolic environment within a cell, is therefore of significant importance.

The corrected figure is now available in both the HTML and PDF versions of the article on the Nature website. The publisher has stated that this correction does not affect the overall conclusions or validity of the research. The authors and Nature encourage readers to refer to the corrected version for accurate information.