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Cancer Research, Weight Loss & Therapy: What's Really Working?

Concerns have been raised regarding the accuracy of data in several scientific papers published in the journal Nature, prompting editorial expressions of concern and corrections. These issues involve potential duplication of images and questionable western blot bands, highlighting the importance of data integrity in scientific research.

According to Nature News, two editorial expressions of concern were issued regarding papers. One concerns a paper titled "Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses," where the editors noted that western blot bands in figures 1e, 3g, and 4c appeared very similar. The authors no longer had the original data to verify the images. The second expression of concern was for a paper titled "Deacetylation of p53 modulates its effect on cell growth and apoptosis," where similar concerns were raised about the western blot bands for total p53 in figure 3. Again, the original data was unavailable for verification. In both cases, the authors, represented by Wei Gu, disagreed with the expressions of concern.

Additionally, a correction was published for the article "The genomic landscape of response to EGFR blockade in colorectal cancer." Nature News reported that a micrograph in Extended Data Fig. 8 was inadvertently duplicated during figure preparation. The image was meant to show phospho-ERK levels in a MAP2K1-mutant patient-derived xenograft exposed to a MEK inhibitor, but was accidentally overlaid with an image from another figure. A corrected version of the figure is now available.

In other news, the demand for GLP-1 drugs has skyrocketed over the last year, with users more than doubling since 2024, according to Vox. As the industry expands, more is being learned about the long-term effects of these drugs. Common side effects include fatigue and nausea.

Vox also reported on the popularity of Internal Family Systems therapy, despite its scientifically shaky claims. The article explored why this therapy style is so popular, even though its claims are dubious.

AI-Assisted Journalism

Synthesized from multiple sources. Reviewed for accuracy.

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