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Nature: Cancer Breakthroughs Clash with Therapy Doubts

Nature Journal Issues Concerns Over Cancer Research, Announces Corrections

LONDON - The prestigious journal Nature has issued an "Expression of Concern" regarding a 2010 paper due to concerns about the similarity of western blot bands in several figures, according to multiple sources. The authors, who no longer have access to the original data, disagree with the concerns. Additionally, Nature announced a correction to a 2015 article, addressing a duplicated image in an extended data figure.

The "Expression of Concern" relates to a paper published online on March 7, 2010, titled "Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses." The editors alerted readers to concerns about western blot bands in Figs. 1e, 3g, and 4c, as reported by Nature News (Source 1, Source 4, Source 5). Specifically, the ULF bands between lanes 1 and 4 in Fig. 3g, and three ARF bands in Fig. 1e and 4c, appeared similar. The authors, led by Wei Gu, stated they disagree with the Expression of Concern. Readers are advised to interpret the results with caution, according to the journal.

The second announcement from Nature involved a correction to an article published on September 30, 2015, concerning the genomic landscape of response to EGFR blockade in colorectal cancer (Source 2). In Extended Data Fig. 8, a micrograph was inadvertently duplicated during figure preparation. The image, intended to show phospho-ERK (P-ERK) levels in a MAP2K1-mutant patient-derived xenograft (PDX) exposed to the MEK inhibitor AZD6244 (AZD), was accidentally overlaid with a micrograph from Extended Data Fig. 10. A corrected version of Extended Data Fig. 8, containing the appropriate image, is now available as a supplement.

These announcements highlight the rigorous peer-review process and the importance of data integrity in scientific publishing. The inability of the authors of the 2010 paper to verify their original data underscores the challenges of long-term data preservation. The corrections also demonstrate the journal's commitment to accuracy and transparency.

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Synthesized from multiple sources. Reviewed for accuracy.

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