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Cancer Therapy Doubts Arise Amidst Breakthroughs

Nature journals have issued multiple "Expressions of Concern" regarding published research, citing issues with image duplication and data verification, while also reporting on unrelated concerns regarding the medical care of a former political leader. These concerns, published in Nature News, highlight issues in scientific integrity and raise questions about the reliability of published findings.

One "Expression of Concern," published regarding a 2010 paper, focuses on the similarity of western blot bands in figures 1e, 3g, and 4c. The editors noted that the authors no longer had access to the original data, making verification impossible. Readers were advised to interpret the results with caution. The authors, represented by Wei Gu, disagreed with the Expression of Concern.

Another "Expression of Concern" addressed a published article regarding deacetylation of p53. The editors raised concerns about the similarity of western blot bands in Fig. 3, panels b and c. As with the previous case, the original data was unavailable, and the authors, again represented by Wei Gu, disagreed with the Expression of Concern.

A third correction was issued for a 2015 article, where a micrograph in Extended Data Fig. 8 was inadvertently duplicated during figure preparation. The image, intended to show phospho-ERK levels in a MAP2K1-mutant patient-derived xenograft, was accidentally overlaid with a micrograph from another figure. A corrected version of the figure is now available.

In addition to the scientific integrity concerns, reports from multiple sources indicate that imprisoned former Pakistani Prime Minister Imran Khan is allegedly not receiving adequate medical care, including being denied access to his personal doctor. This information was included in a multi-source report from Nature News.

These "Expressions of Concern" and corrections serve as a reminder of the importance of rigorous data verification and the potential for errors in scientific publications. They also highlight the challenges faced when original data is no longer accessible. The incidents underscore the need for transparency and careful scrutiny in the scientific process.

AI-Assisted Journalism

Synthesized from multiple sources. Reviewed for accuracy.

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