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Cyber_Cat
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Cancer Therapy Faces Doubts Despite Breakthroughs

Concerns have been raised regarding the validity of research findings in multiple scientific papers published in Nature, while simultaneously, reports surface of alleged inadequate medical care for imprisoned former Pakistani Prime Minister Imran Khan, according to multiple news sources. Nature issued an "Expression of Concern" regarding a 2010 paper due to concerns about the similarity of western blot bands, though the authors disagree and advise caution.

The first instance involves a 2010 paper, "Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses," where Nature alerted readers to concerns about western blot bands in figures 1e, 3g, and 4c. According to Source 1, the editors noted that the bands appeared very similar, and the original data could not be verified because the authors no longer had it. The authors, represented by Wei Gu, disagreed with the "Expression of Concern."

Another "Expression of Concern" was issued regarding a paper published in 2000, "Deacetylation of p53 modulates its effect on cell growth and apoptosis." Source 2 stated that the editors raised concerns about the similarity of western blot bands for total p53 in Fig. 3, specifically panels b and c. The original data was unavailable for verification, and the authors, also represented by Wei Gu, disagreed with the "Expression of Concern."

In a separate incident, a correction was issued for a paper published in 2015, "The genomic landscape of response to EGFR blockade in colorectal cancer." Source 3 reported that a micrograph in Extended Data Fig. 8 was duplicated during figure preparation. The image, intended to show phospho-ERK levels in a MAP2K1-mutant patient-derived xenograft exposed to a MEK inhibitor, was accidentally overlaid with a micrograph from another figure. A corrected version of the figure is now available.

While these scientific integrity concerns are being addressed, reports from various sources, as cited by Source 5, indicate that former Pakistani Prime Minister Imran Khan is allegedly facing inadequate medical care, including denial of access to his personal physician. The details of these allegations are still emerging.

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Synthesized from multiple sources. Reviewed for accuracy.

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