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Cancer Therapy Faces Doubts, New Threats Emerge

Concerns regarding the integrity of scientific data and image duplication have surfaced in two separate articles published in the journal Nature, according to reports from Nature News. One article, focusing on cancer research, had a micrograph inadvertently duplicated, while another raised questions about the validity of western blot bands. These corrections highlight the ongoing scrutiny of scientific publications and the importance of data accuracy.

The first correction, detailed in Nature News, addressed an article titled "Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses," published online on March 7, 2010. The editors issued an "Expression of Concern" regarding western blot bands in figures 1e, 3g, and 4c. Specifically, the ULF bands between lanes 1 and 4 in Fig. 3g, and the three ARF bands between lanes 2 and 4 in Fig. 1e and lanes 1 and 3 in Fig. 4c, appeared similar. The authors could not verify the images due to the unavailability of the original data. The authors, through Wei Gu, stated they did not agree with the Expression of Concern.

The second correction, also reported by Nature News, involved an article on "The genomic landscape of response to EGFR blockade in colorectal cancer," originally published on September 30, 2015. A micrograph in Extended Data Fig. 8 was duplicated during figure preparation. The image, intended to show phospho-ERK (P-ERK) levels in a MAP2K1-mutant patient-derived xenograft (PDX) exposed to the MEK inhibitor AZD6244 (AZD), was accidentally overlaid with a micrograph from Extended Data Fig. 10, displaying P-ERK levels in an EGFR-mutant PDX exposed to panitumumab (PAN). A corrected version of Extended Data Fig. 8 is now available.

These corrections are part of a broader trend of scrutiny within scientific publishing. Nature News reported that this week's news included these corrections alongside other significant developments. The corrections underscore the importance of rigorous data verification and the potential for errors in the scientific process.

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