A published research article in the journal Nature is under scrutiny. Editors issued an expression of concern regarding a PCR gel image in Fig. 4a of the 1998 paper. The article, titled "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM," is facing questions about data integrity.
The concern focuses on potential similarities in the bottom halves of lanes B3 and B1 within the PCR gel image. The article was published online October 1, 1998. The research was conducted by scientists at multiple institutions, including Beth Israel Deaconess Medical Center and Harvard Medical School.
The journal Nature alerted readers to the concerns. The institutions involved may launch internal reviews. The findings of the original paper could be impacted.
The study investigated the role of the SAP protein in X-linked lymphoproliferative disease (XLP). XLP is a rare immune deficiency. The research aimed to understand how SAP regulates immune cell signaling.
Further investigation is needed to determine the extent of the issue. The journal and involved institutions are expected to provide updates as they become available. The scientific community awaits clarification on the validity of the data.
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