A correction has been issued for a research article published in Nature on January 14, 2026, concerning polyamine-dependent metabolic shielding and its influence on alternative splicing. The original article, which explored the intricate relationship between cellular metabolism and RNA processing, contained an error in Figure 1g. Specifically, the labels "24 h" on the three right-hand side of the figure were incorrectly labeled and should have read "SAT1," "SMARCA1," and "ACTB."
The correction addresses a labeling error within a figure illustrating experimental results related to the study's findings. Alternative splicing is a crucial biological process that allows a single gene to code for multiple proteins by selectively including or excluding different segments of RNA. Metabolomics, the comprehensive study of small molecules within cells and organisms, provides a snapshot of metabolic activity. The corrected figure is intended to accurately represent the experimental data supporting the article's conclusions about how polyamines, organic compounds essential for cell growth and differentiation, mediate the connection between metabolism and alternative splicing.
The authors of the study are affiliated with the Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), located in Derio, Spain. Key researchers involved include Amaia Zabala-Letona and Mikel Pujana-Vaquerizo, who are listed as having contributed equally to the work, along with Belen Martinez-Laosa, Maria Ponce-Rodriguez, and numerous other colleagues.
The error was identified by the authors and brought to the attention of Nature, prompting the publication of the correction. The corrected version of the article is now available in both HTML and PDF formats on the Nature website. The publisher has updated the online versions of the article to reflect the change. This type of correction is standard practice in scientific publishing to ensure the accuracy and reliability of published research. The correction does not affect the overall conclusions of the study, but clarifies the presentation of the data in Figure 1g.
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