A publisher's correction has been issued for a research article in Nature regarding the role of oestradiol in inhibiting ferroptosis and acute kidney injury, initially published online August 13, 2025. The correction addresses errors introduced during the typesetting process that were not present in the peer-reviewed version of the manuscript or the original data.

According to the publisher's note, the errors did not affect the scientific conclusions of the study. The corrections primarily involve inaccuracies in chemical structures within figures and discrepancies in sample sizes reported in figure legends. Specifically, Figure 2e incorrectly displayed the chemical structure for 4OH-E2 instead of 17β-estradiol, and Figure 2f contained an error in the 2OH-E2 structure. Additionally, Figures 2o, 2p, and 2q contained incorrect sample sizes for Sham and IRI OVX mice. The publisher also noted incorrect references to Extended Data figures on pages 1011 and 1012.

The original article explored the multiple functions of oestradiol, a primary female sex hormone, in mitigating ferroptosis, a form of cell death driven by iron and lipid peroxidation, and its subsequent impact on acute kidney injury. The research investigated the mechanisms by which oestradiol and its metabolites protect against kidney damage in preclinical models.

Researchers in the field suggest that understanding the protective mechanisms of oestradiol could lead to the development of novel therapeutic strategies for preventing or treating acute kidney injury, a condition with limited treatment options. The study's findings contribute to the growing body of knowledge on the complex interplay between hormonal regulation, cellular stress, and organ health.

The publisher has updated the online version of the article to reflect these corrections. Readers are advised to refer to the corrected version for accurate information. The Nature journal's policy is to issue corrections promptly to ensure the integrity of the scientific record.