A publisher's correction has been issued for a research article in Nature concerning the role of oestradiol in inhibiting ferroptosis and acute kidney injury, initially published online August 13, 2025. The correction addresses errors introduced during the typesetting process that were not present in the peer-reviewed version of the manuscript or the original data.

The errors included incorrect chemical structures in figures 2e and 2f, where the structure for 4OH-E2 was mistakenly placed instead of 17β-estradiol in figure 2e, and in figure 2f, the 2OH-E2 structure contained "H" instead of "HO" in the upper left corner. Discrepancies were also found in the sample sizes reported in figures 2o, 2p, and 2q for Sham and IRI OVX mice, and incorrect references were made to Extended Data figures 2ac, 2d, and 2e, which were incorrectly cited as Extended Data figures 3ac, 3d, and 3e. The publisher clarified that these errors do not affect the scientific conclusions of the study.

Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, is implicated in various diseases, including acute kidney injury (AKI). The original article explored the protective effects of multiple oestradiol functions against ferroptosis in the context of AKI. Oestradiol, a primary female sex hormone, has been investigated for its potential therapeutic applications beyond hormone replacement therapy.

The research, before the correction, suggested that oestradiol and its metabolites could play a significant role in mitigating kidney damage by inhibiting ferroptosis. The study investigated the mechanisms through which oestradiol exerts its protective effects, potentially opening new avenues for the development of treatments for AKI and related conditions.

The publisher's note emphasizes that the corrections are purely technical and do not alter the core findings or interpretations of the research. The corrected article is now available on the Nature website. Researchers and clinicians are advised to refer to the updated version for accurate information.