A publisher's correction has been issued for an article in Nature regarding the role of oestradiol in inhibiting ferroptosis and acute kidney injury, initially published online August 13, 2025. The correction addresses errors introduced during the typesetting process that were not present in the peer-reviewed version of the manuscript or the original data.

The errors included incorrect chemical structures in Figure 2e and 2f, where the structure for 4OH-E2 was mistakenly used instead of 17β-estradiol in Figure 2e, and in Figure 2f, the 2OH-E2 structure contained "H" instead of "HO" in the upper left portion. Discrepancies were also found in Figure 2o, 2p, and 2q, concerning the number of mice used in Sham and IRI OVX groups, where labels initially read "n 2" and "n 5" instead of the correct "n 6," and "n 2" instead of "n 5," respectively. Furthermore, Extended Data Figures 2ac, 2d, and 2e were incorrectly referenced as Extended Data Figures 3ac, 3d, and 3e on pages 1011 and 1012 of the published article.

According to the publisher's note, these errors do not affect the scientific conclusions of the study. The research explores the multiple functions of oestradiol, a primary female sex hormone, in mitigating ferroptosis, a form of cell death driven by iron and lipid peroxidation, and its subsequent impact on acute kidney injury. The study investigated the mechanisms by which oestradiol and its metabolites influence cellular processes related to oxidative stress and cell survival in the context of kidney health.

Ferroptosis has become an area of increasing interest in biomedical research, with potential implications for various diseases, including cancer, neurodegenerative disorders, and organ damage. Understanding the molecular pathways involved in ferroptosis and identifying potential therapeutic targets is a key focus for researchers. The original article in Nature presented data suggesting that oestradiol plays a protective role against ferroptosis-induced kidney damage, potentially opening avenues for novel therapeutic interventions.

The publisher has corrected the online version of the article to reflect the accurate chemical structures and sample sizes. Readers are advised to refer to the corrected version for accurate information. The publisher stated that they are committed to ensuring the accuracy and integrity of published research and regret any confusion or inconvenience caused by these errors.