Scientists have uncovered a key reason why some chronic wounds resist healing, even when treated with antibiotics, according to research published January 20, 2026, by Nanyang Technological University, Singapore (NTU Singapore). The international research team discovered that a common bacterium found in long-lasting wounds actively releases damaging molecules that overwhelm skin cells and prevent tissue repair.

The study revealed that these bacteria, often present in chronic wounds, do more than just resist antibiotic drugs. They actively sabotage the healing process by releasing harmful molecules. Researchers found that neutralizing these molecules with antioxidants allows skin cells to recover and restart the healing process. This suggests a potential shift in treatment strategies for chronic wounds, focusing on neutralizing these damaging molecules rather than solely relying on antibiotics.

Chronic wounds represent a significant and growing global health challenge. Diabetic foot ulcers alone affect approximately 18.6 million people worldwide each year. Over a lifetime, it is estimated that as many as one in three people will develop a chronic wound. These wounds can lead to serious complications, including infections, amputations, and a decreased quality of life. The increasing prevalence of antibiotic-resistant bacteria further complicates the treatment of these wounds.

The research team, led by NTU Singapore, identified the specific molecules released by the bacteria that inhibit wound healing. They then demonstrated that antioxidants could effectively neutralize these molecules, allowing skin cells to recover and resume the repair of damaged tissue. This finding offers a promising new avenue for developing more effective treatments for chronic wounds, particularly those infected with antibiotic-resistant bacteria.

The implications of this discovery extend beyond traditional medical treatments. The research highlights the complex interplay between bacteria and the human body, suggesting that a more holistic approach to wound care, focusing on modulating the wound environment, may be more effective than simply targeting the bacteria with antibiotics. Further research is underway to identify specific antioxidants that are most effective in neutralizing the damaging molecules and to develop new wound dressings and therapies that incorporate these antioxidants. The team is also exploring the potential of using AI-powered diagnostics to identify the specific types of bacteria present in a wound and to tailor treatment accordingly.